Work

Normalizing Uricemia in Psoriatic Arthritis: A Hypothetical Reduction of Atherosclerotic Plaque Burden

Year: 2026

Type: article

Abstract: Hyperuricemia has long been recognized as the biochemical substrate for gout, but growing evidence suggests that it may also contribute to cardiovascular (CV) disease. Psoriatic inflammation, dominated by interleukin (IL)-23/IL-17 and tumor necrosis factor, amplifies endothelial activation (increase in vascular cell adhesion molecule 1), oxidative stress, and neutrophil extracellular trap formation (ie, NETosis), priming the arterial wall for atherogenesis.

Source: The Journal of Rheumatology

DOI: 10.3899/jrheum.2025-0992

Authors: Rubén Queiro, Marta Loredo, Estefanía Pardo, Ignacio Braña

Institutions: Universidad de Oviedo, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias

Language: English

Topic: Gout, Hyperuricemia, Uric Acid

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7128949545