Recent Advances in DNA-Encoded Library: High-Throughput Identification of Chemical Inducers of Proximity from Degraders to Non-degraders
Year: 2026
Type: article
Abstract: DNA-encoded library (DEL) technology has emerged as a transformative platform for discovering chemical inducers of proximity (CIPs), addressing challenges in both degrader and non-degrader CIP development. This Microperspective analyzes the results of recent DEL technology screens (2021-2025) to enable medicinal chemistry programs, focusing on CIP development including CIP-focused DELs, DEL-derived ligands for proteins of interest (POIs) and E3 ligase in rational CIP design, and directly functional CIP identification. Finally, we address current limitations of DEL technology in CIP research and outline future directions. This Microperspective underscores DEL's pivotal role in advancing CIP discovery, providing actionable insights for addressing "undruggable" targets and accelerating translational research in chemical biology and medicinal chemistry.
Source: ACS Medicinal Chemistry Letters
Authors: Yulong An, Ruolan Zhou, Xiang Li
Institution: Zhejiang University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7128950696