Work

A Double-Edged Sword: Extracellular Serine Proteases as Facilitators of Infection and Mediators of Immunity

Year: 2026

Type: article

Abstract: Serine proteases are a class of enzymes that orchestrate an immune response. These proteases can be hijacked by viruses to facilitate entry and spread, while simultaneously supporting the innate immune system in neutralizing pathogens. This review highlights the dual roles of exogenous serine proteases, emphasizing neutrophil serine proteases (NSPs) that facilitate viral entry and promote disease progression while also contributing to antiviral defense by degrading viral glycoproteins. Additionally, the potential to modulate serine protease activity to boost host defenses will be discussed, offering both significant challenges and new opportunities for therapeutic intervention.

Source: Molecules

DOI: 10.3390/molecules31040670

Authors: Alua Shagirova, Maiya Allayarova, Aiya Makhanova, Amanbek Bekturgan, Timo Burster

Institution: Nazarbayev University

Language: English

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258