Work

The human induced pluripotent stem cell line CTGUi-002A was generated from a Perrault syndrome patient

Year: 2026

Type: article

Abstract: We generated an induced pluripotent stem cell (iPSC) line, designated CTGUi002-A, from peripheral blood mononuclear cells (PBMCs) of a 9-year-old female with Perrault syndrome carrying biallelic TWNK mutations (c.811G>A and c.1163C>T), using Sendai virus-mediated delivery of OCT4, SOX2, KLF4, and c-MYC. The CTGUi002-A iPSC line retained the TWNK mutations and exhibited characteristic iPSC morphology, expressed pluripotency markers, maintained a normal karyotype, and demonstrated trilineage differentiation potential.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2026.103929

Authors: Shen-lin Wu, Yang Li, Tonghai Dou, Wei Wang, Jing-qiong Zhan, Ya-feng Lv

Institutions: China Three Gorges University, China-Japan Friendship Hospital

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,360