Work

The Difluorinative Acetonylation of Imidazopyridine Using Acetophenone and Selectfluor

Year: 2026

Type: article

Abstract: We have developed an approach for the geminal difluorinative vicinal acetonylation of imidazo[1,2‐ a ]pyridines using selectfluor and aryl methyl ketones. This strategically designed nucleophilic addition of aryl methyl ketone to imidazopyridine was achieved through the geminal difluorination of imidazo[1,2‐ a ]pyridine using selectfluor. The method resulted in the formation of two CF bonds, one CC bond, and a quaternary stereocenter. This mild, efficient, and cost‐effective method offers a broad substrate scope and successfully extended to benzimidazothiazole derivatives.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500995

Authors: Vijaya Rani Potluri, Saradhi Kalari, Akash Shinde, Shivani Maykalwar, Sagar Patil, Yeshwant Gajbhare, Avinash Puyad, Jagadeesh Babu Nanubolu, Haridas B. Rode

Institutions: Indian Institute of Chemical Technology, Academy of Scientific and Innovative Research

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

Funder: Indian National Science Academy

OpenAlex ID: W7128974181

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Cites: 39

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