Novel Sulfated Alginate-Cerium Bioactive Glass Scaffolds: Promising Platform for Cardiac Tissue Regeneration.
Year: 2026
Type: article
Abstract: Objective: Cardiovascular diseases remain a leading cause of global mortality and morbidity, despite advances in prevention, diagnosis, and treatment. Cardiac tissue engineering (CTE) offers a promising approach to repairing damaged myocardium through bioengineered constructs that closely mimic native cardiac tissue. The integration of biomaterials that enhance angiogenesis, exhibit antioxidant activity, and support cellular proliferation can further improve regenerative outcomes. This study aimed to assess the potential of a sulfated alginate (S-Alg)/cerium-doped 45S5 bioactive glass (Ce-BG) scaffold as a cardiac patch for tissue engineering applications. Materials and Methods: In this experimental study, novel porous scaffolds composed of S-Alg and Ce-BG were fabricated using a freeze-drying technique. The scaffolds underwent comprehensive physicochemical characterization and cytocompatibility evaluation. Their angiogenic potential was assessed by quantifying vascular endothelial growth factor receptor 2 (VEGFR2) expression using quantitative reverse transcription polymerase chain reaction (qRT-PCR) over a seven-day period. Additionally, scaffold antioxidant activity was assessed using the DPPH assay. Results: in HUVECs cultured on Ce-containing scaffolds over seven days. Moreover, the addition of Ce enhanced the antioxidant activity of BG-containing scaffolds, effectively scavenging DPPH radicals over time, highlighting their potential for cardiac patch applications. Conclusion: The S-Alg/Ce-BG composite scaffold exhibits favorable properties for CTE, including cytocompatibility, enhanced angiogenic potential, and antioxidant activity. These features highlight the scaffold as a highly promising candidate for advancing cardiac tissue regeneration strategies.
Source: PubMed
Authors: Fatemeh Forouzandeh, Abdullah Aldhaher, Nafiseh Baheiraei, Fatemeh Shams, Ali Doostmohammadi, Heshmat Allah Samimi
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7128994308
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