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Ruptured Sinus of Valsalva Aneurysm in a Patient with Mixed Connective Tissue Disease: Case Report

Year: 2026

Type: article

Abstract: Sinus of Valsalva aneurysm is a rare cardiac anomaly, affecting approximately 0.09 % of the population. Its rupture represents a life-threatening event that can rapidly lead to heart failure. We report a 32-year-old woman with mixed connective tissue disease presenting with right-sided heart failure. Echocardiography demonstrated a ruptured right coronary cusp sinus of valsalva aneurysm into the right ventricle with moderate aortic regurgitation. Surgical repair was successfully performed, and histopathology supported an autoimmune-mediated etiology. To our knowledge, this is the first reported case of ruptured sinus of valsalva aneurysm occurring in a patient with autoimmune mixed connective tissue disease.

Source: Journal of the Saudi Heart Association

DOI: 10.37616/2212-5043.1472

Authors: Kenzo Adhi Wiranata, Pramadya Vardhani Mustafiza, Enrico Ananda Budiono

Institution: Sebelas Maret University

Language: English

Topic: Aortic Disease and Treatment Approaches

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7129001879

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