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Development of a Late-Stage Functionalization Strategy to Access Diverse 3,5-Disubstituted 1,2,4-Thiadiazoles

Year: 2026

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Efforts to prepare amine-substituted 1,2,4-thiadiazoles typically incorporate chemical diversity in the early steps of the reaction sequence or through amine choice in coupling and aromatic substitution reactions. We developed a late-stage functionalization approach that enables facile incorporation of complex substituents and diverse nitrogen-containing functional groups at C 3 and C 5 .

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c02935

Authors: Andrew Dobria, Zoe A. Petros, Philip Mickel, Leslie N. Aldrich

Institutions: National Institutes of Health, University of Illinois Chicago, National Cancer Institute, National Cancer Institute, Center for Cancer Research

Language: English

Topic: Structural and Chemical Analysis of Organic and Inorganic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: University of Illinois at Chicago, National Cancer Institute