Work

Generation of two isogenic sickle cell disease induced pluripotent stem cell lines from ovarian fibroblasts

Year: 2026

Type: article

Abstract: Curative bone marrow transplantation (BMT) therapies for sickle cell disease (SCD) can cause infertility. The Fertility Preservation Program (FPP) in Pittsburgh cryopreserves ovarian tissues for SCD patients prior to BMT in anticipation that these tissues can be used in the future to produce eggs and achieve a pregnancy. Here, we generated and validated two isogenic patient-derived induced pluripotent stem cell (iPSC) lines from ovarian cortex fibroblasts of a 28-year-old SCD patient.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2026.103936

Authors: Mitchell R. Harancher, Livianna K. Myklebust, Meena Sukhwani, Charvi Kanodia, Yi Sheng, Carlos A. Castro, Amanda M. Colvin Zielen, Kyle E. Orwig

Institutions: University of Pittsburgh, Magee-Womens Research Institute, Magee-Womens Hospital, University of Pittsburgh Medical Center, University of Edinburgh, UPMC Health System

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,360

Funders: Magee-Womens Research Institute, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G304910948, G5310689819, G7846871816, G8400937683

OpenAlex ID: W7129004054

FWCI:

Cites: 6

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