The Anti-proliferative and Pro-apoptotic Effects of Iranian Viper Venom (Vipera raddei kurdistanica) on Human Gastric Cancer Cells (C615) are Mediated by PI3K/AKT/mTOR Signalling Pathway Inhibition.
Year: 2026
Type: article
Abstract: Objective: venom on human GC cells (C615). Materials and Methods: ) concentration was evaluated using the TUNEL, annexin V/PI flow cytometry, and diphenylamine DNA fragmentation assays. Mitochondrial membrane potential (JC-1), cytosolic cytochrome c levels, and the expressions of apoptosis-related and PI3K/ AKT/mTOR pathway genes were measured. All experiments were performed in three independent biological replicates. Results: (P<0.001). Conclusion: venom may exert selective cytotoxic effects against gastric cancer cells and may induce apoptosis through both intrinsic and extrinsic pathways, potentially via inhibition of the PI3K/AKT/mTOR signalling axis.
Source: PubMed
Authors: Cyrus Jalili, Mona Pazhouhi, Mohammadreza Gholami, Fuzieh Khani-Hemmatabadi, Keyvan Maleki
Institution: Kermanshah University of Medical Sciences
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7129008251
FWCI:
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