Work

The Potential of Non-Ribosomal Peptide Engineering for Creating New Antimicrobial Complexes

Year: 2026

Type: article

Abstract: Self-assembling antimicrobial complexes are a promising new technology for the development of antimicrobial, antifungal, and other bioactive agents with targeted delivery, adaptability, and the regulation of processes over time. Ribosomally synthesized antimicrobial peptides (AMPs) are most frequently considered as the basis for such complexes; however, we suggest that non-ribosomally synthesized peptides (NRPs) should be considered as molecules that also hold potential for engineering and already possess a set of qualities that AMPs are still to be engineered to have. This review examines the key features of NRP structure and self-assembly that determine their potential as antimicrobial agents, as well as NRP engineering methods through which new, more advanced agents for combating antibiotic-resistant microorganisms can be created.

Source: Molecules

DOI: 10.3390/molecules31040683

Authors: Evgeniya V. Prazdnova, Maxim P. Kulikov, Ludmila E. Khmelevtsova

Institution: Southern Federal University

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258