Work

General anesthesia in patient with Hutchinson-Gilford Progeria syndrome: two case reports of dental treatment in the one patient

Year: 2026

Type: article

Abstract: BACKGROUND: Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder that manifests itself in premature aging. Craniofacial and skeletal abnormalities, cardiovascular pathology, concomitant cerebrovascular diseases, and potential airway problems in HGPS significantly increase the degree of anesthetic risk and make anesthetic management more challenging in these patients. CASE PRESENTATION: We present the case of the girl with HGPS who undertook two episodes of dental treatment using general anesthesia at the ages of 8 and 10 years old. In both cases, airway was secured by fiberoptic intubation. CONCLUSION: This case increases the awareness of HGPS and the features of anesthesia in patients with HGPS. For long-term dental treatment, general anesthesia with tracheal intubation using fiberoptic access is the optimal method of anesthesia in these patients.

Source: BMC Anesthesiology

DOI: 10.1186/s12871-026-03701-6

Authors: B. Mankovsky, O. Halushko, Y. Zablotskyy, M. Synytsyn

Institutions: D. F. Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, National Academy of Medical Sciences of Ukraine

Language: English

Topic: Airway Management and Intubation Techniques

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190