Therapeutic Landscape of HPV-Associated Cancers: From Mechanisms and Conventional Approaches to Future Innovations
Year: 2026
Type: article
Abstract: Cancer remains the second leading cause of mortality worldwide. Human papillomavirus is a widespread DNA virus with well-established oncogenic potential, particularly among high-risk genotypes such as HPV16 and HPV18. Persistent infection with these genotypes can lead to the development of several malignancies, including cervical, oropharyngeal, anal, penile, vulvar, and vaginal cancers. Cervical cancer persists as the most prevalent malignancy associated with HPV infection, disproportionately affecting low- and middle-income countries. This review provides an overview of the HPV genome, viral genotypes, and associated malignancies, with particular emphasis on the viral oncoproteins E6 and E7 and the mechanisms of viral DNA integration into the host genome. In addition, recent advances in diagnostic technologies, therapeutic strategies, ongoing clinical trials, and future directions to reduce the global burden of HPV-related cancers are discussed.
Source: Cancers
Institution: Griffith University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Funder: Griffith University
OpenAlex ID: W7129019111