Work

Highly Sensitive Rhodol‐Based Fluorescent Probe for Detecting Hydrogen Peroxide in Cells and Zebrafish

Year: 2026

Type: article

Abstract: ABSTRACT As a critical reactive oxygen species (ROS), hydrogen peroxide (H 2 O 2 ) plays a significant role in regulating oxidative stress, which closely relates to various human diseases. Therefore, it is of great significance to sensitively detect H 2 O 2 and elucidate its physiological function. Herein, a fluorescent probe was present for detecting H 2 O 2 in living cells and zebrafish. It exhibited highly selective and sensitive responses in the presence of H 2 O 2 with a detection limit of 142.18 nM. The probe was successfully applied to detect endogenous and exogenous H 2 O 2 in living cells and zebrafish. All the results in this work demonstrated that the probe was a powerful tool for detecting H 2 O 2 and exploring the roles of H 2 O 2 in various physiological and pathological processes.

Source: Luminescence

DOI: 10.1002/bio.70449

Authors: Mingshuo Ma, Bingxin Zhu, Jiaqi Yu, Shanshan Wang, Shihua Yu, Xiaodan Zeng

Institution: Jilin University of Chemical Technology

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, People's Government of Jilin Province, Department of Science and Technology of Jilin Province

Awards: G7621147381, G8928522675