Work

The glycan fingerprint in immune thrombocytopenia

Year: 2026

Type: article

Abstract: A state-of-the-art lecture titled "Platelet Glycobiology and Immune Thrombocytopenia (ITP)" was presented at the International Society on Thrombosis and Haemostasis (ISTH) congress in 2025. In this review, we summarize the current knowledge on glycan-mediated mechanisms in ITP, including glycan alterations of platelet autoantibodies and on the surface of platelets and megakaryocytes. We discuss how these glycan modifications might contribute to thrombocytopenia, and potentially to an increased risk of bleeding in patients with ITP. We address relevant new data on this topic and emphasize key directions for future ITP glycobiology research.

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2026.103388

Authors: Vivianne S. Nelson, Jan Zlamal, Rick Kapur