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Supplementary File S1 from PCSK5M452I Is a Recessive Hypomorph Exclusive to MCF10DCIS.com Cells

Year: 2026

Type: supplementary-materials

Abstract: DEseq2 analysis of 3D spheroids prepared from MCF10DCIS.com cells reconstituted with wild-type (WT), hypomorphic (M452I), or null (T288P) PCSK5, and PCSK5T288P cultured with 250 ng/mL GDF11 for 8 days. Worksheets compare GDF11 relative to T288P, WT relative to T288P, and WT relative to M452I. Each sheet reports the log2 fold change, standard error (SE), DEseq2 statistics, and the mean and modeled counts for each condition from N = 4 biological replicates.

DOI: 10.1158/1541-7786.31348204

Authors: Taylor Marohl, Kristen A. Atkins, Lixin Wang, Kevin A. Janes

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7129031378

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