PrecISE—a biomarker-stratified adaptive trial of 5 interventions in severe asthma: Final protocol and the baseline cohort
Year: 2026
Type: article
Authors: Loren C. Denlinger, Loren C. Denlinger, Elliot Israel, Wendy C. Moore, Steve N. Georas, Rosalind J. Wright, Mario Castro, David B. Peden, Kevin J. Anstrom, Eugene R. Bleecker, Laura Crotty Alexander, Katherine N. Cahill, Juan Carlos Cardet, Tara F. Carr, Jorge Cedano, Anita Y. Chen, Geoffrey L. Chupp, Suzy A.A. Comhair, Emily A. DiMango, Serpil C. Erzurum, John V. Fahy, Merritt L. Fajt, Benjamin M. Gaston, Daniel J. Jackson, Sonia Jain, Nizar N. Jarjour, Nicholas J. Kenyon, Monica Kraft, Jerry A. Krishnan, Rajesh Kumar, Njira L. Lugogo, Fernando D. Martinez, M. Alison Marquis, Andrea A. Pappalardo, Wanda Phipatanakul, Matthew A. Rank, Sharon R. Rosenberg, Justin D. Salciccioli, Maria Sanchez, Lewis J. Smith, Kaharu Sumino, Stanley J. Szefler, Monica Tang, Pandurangan Vijayanand, Michael E. Wechsler, Sally E. Wenzel, Steven R. White, Amir A. Zeki, Anastasia Ivanova, Leonard B. Bacharier, Praveen Akuthota, Eugene R. Bleecker, Tara F. Carr, Wendy C. Moore, Matthew A. Rank, Gabriel Camacho, Lynn B. Gerald, Annette Hastie, Jeffrey O. Krings, Fernando D. Martinez, Janell L. Merchen, Deborah A. Meyers, Nirushan Nirendran, Victor E. Ortega, Anna Pippins, Annie M. Rusk, Ronald Schunk, Raymond Skeps, Temeka Simmons, Paul Williamson, Joe Zein, Elliot Israel, Juan Carlos Cardet, Emily A. DiMango, Wanda Phipatanakul, Jonathan Bailey, Tina M. Banzon, Lisa M. Bartnikas, Sachin N. Baxi, Vishwanath Betapudi, Isabelle Brick, Thomas B. Casale, Maria Angeles Cinelli, Elena Crestani, Amparito Cunningham, Brittany Esty, Eva Fandozzi, Jesse Fernandez, Elizabeth Fitzpatrick, Brenda Flam, Victoria E. Forth, Jonathan M. Gaffin, Katarina Gentile, Seyni Gueye-Ndiaye, Kathleen Haley, Ray Heromin, Marissa Hauptmann, Tiffani Kaage, Michael Kelly, Michelle Kraemer, Brenna LaBere, Peggy Sue Lai, Meghan Le, Dennis K. Ledford, Jasmine Lee, Julia Lee, Richard Lockey, Andrew J. Macginnitie, Kimberly McCarty, Katherine Moss, Lana Mukharesh, Allison O'Neil, Carrie Pistenmaa, Amber N. Pepper, Maureen Pimental, Dianna Queheillalt, Alexis Robinson, Justin Salciccioli, Tarnjot Saroya, Catherine Smith, Michelle Trevedi, Lorenzo Trippa, Abigail Tulchinsky, Alexis Vitiello, Christina Yee, Kelly Zakar, Steven R. White, Rajesh Kumar, James N. Moy, Sharon R. Rosenberg, Hannah Aalemansour, Killian Buechler, Tina Carter, Jun Fu, Jenny Hixon, Carly Jackson, Yuan Ji, Christian Johnson, Ravi Kalhan, John Kane, Opinderjit Kaur, Grace Li, Elizabeth Lippner, Melanie M. Makhija, Spring Maleckar, Edward T. Naureckas, Sharmilee Nyenhuis, Anju T. Peters, Valerie Press, Mehreen Qureshi, Dominika Ryba, Jianrong Sheng, Lewis J. Smith, Ben Xu, Michael E. Wechsler, Stanley J. Szefler, Geoffrey Chupp, Fernando Holguin, Monica Kraft, Andrew H. Liu, Linda Rogers, Darci Anderson, Sonya Belimezova, Jennifer Bitzan, Sonali Bose, James Brock, Juana Cerna Sanchez, Brian J. Clark, Lauren Cohn, Ani Cotarian, Elliot Eisenberg, Jean Estrom, Isabel Glassmeyer, Jose Gomez Villalobos, Nicole Grant, Barr Gruberg, Vamsi P. Guntur, Olivia Hay, Abigail Hills, Jessica Hsieh, Jonathan Kessler, Christena Kolakowski, Naomi Miyazawa, Juno Pak, Diana M. Pruitt, Sarah Rhoads, Sunita Sharma, Allen D. Stevens, Brooke Tippin, Karissa Valente, Alfin Vicencio, Cynthia L. Wainscoat, Jennifer Weber, Grace Wessels, Michael P. White, Daniel Winnica, Pamela L. Zeitlin, Loren C. Denlinger, Loren C. Denlinger, Nizar N. Jarjour, Jerry A. Krishnan, Neha Agnihotri, Julia Bach, Nicole M. Bires, Julie DeLisa, Paul S. Fichtinger, Heather Floerke, Bailee Fritz, Jenelle Grogan, Arturo G. Guadarrama, Wendy Hasse, Daniel J. Jackson, Rachel Kaspari, Rick L. Kelley, Danika Klaus, Paige Lowell, Liana Miranda Larson, Lourdes M. Norwick, Matthew J. O’Brien, Tina Palas, Andrea A. Pappalardo, Elizabeth Read, Angela Schraml, Mark L. Schiebler, Ronald L. Sorkness, Matthew C. Tattersall, Lori Wollet, Benjamin Gaston, Serpil C. Erzurum, W. Gerald Teague, James F. Chmiel, Kristie R. Ross, Mark A. Aronica, Brittany Beck, Lisa Bendy, Larry Borish, Celine Chedraoui, Suzy A.A. Comhair, Michael D. Davis, Aska Dix, Battoul Fakhry, Rebecca Gammell, Adam Gluvna, Emma Hamm, Mary Heskett, Bo Hu, Sumita Khatri, John Kirwan, Kirsten M. Kloepfer, Michelle Koo, Monica Labadia, Angela Marko, Nicole Matheis, Jacob Mey, Anny Mulya, Deborah Murphy, Rachel Owensby, Laura Parker, Emily Pennington, Erica A. Roesch, Jackie Sharp, Kevin Smith, Neha Solanki, Laura Veri, Kristin Wavell Shifflett, Fanmuyi Yang, Sally E. Wenzel, Njira Lugogo, Amir Behzad Bagheri, Linda Cislo, Merritt L. Fajt, Marc Gauthier, Mike Hadden, Pam James, Arjun Mohan, John Moore, Seyed Mehdi Nouraie, Richard Ramonell, Rachel Romanek, Logan Sullivan, John B. Trudeau, Michael Zhang, Praveen Akuthota, Sonia Jain, Pandurangan Vijayanand, Jeffrey Barry, Nuzhat Beg, Howard Brickner, Laura Crotty Alexander, Damaris Diaz, Yasaman Jafari, Nancy McKeon, John V. Fahy, Nicholas J. Kenyon, Rogelio Almario, Annabelle Charbit, Luke Cho, Barbara Gale, Angela Haczku, Richart W. Harper, Travis Houston, Christopher Kain, Celeste Kivler, Brooks T. Kuhn, Donna Liu, Paula McCourt, Jennifer Miller, Anh Nguyen, Xavier Orain, Michael C. Peters, Audrey Plough, Karla Ramirez, Leah Rossi, Michael Schivo, Amisha Singapuri, Suzanne Teuber, Tina Tham, Daniel Tompkins, Jade Vi, Amir A. Zeki, Mario Castro, Leonard B. Bacharier, Kaharu Sumino, Jarron Atha, Jonathan S. Boomer, Katherine Cahill, Amber Clover, Victoria Dorman, Eric A. Hoffman, Fatima Jackson, Miranda Klinck, James Krings, Julie Madison, Jamie Quigley, Tammy Quinones, Shikha Saxena, Matthew Sharpe, Jennifer Troyer, Huiqing Yen-Declue, Abigail Zulich, Anastasia Ivanova, Kevin J. Anstrom, Lisa M. LaVange, Sarah Bagaason, Ashley Britt, Hope Bryan, Allison J. Burbank, Anita Y. Chen, Christopher Culpepper, Forrest DeMarcus, Christy Fenu, Nathan Gotman, Rebecca Green, Lee Harrison, John James, Jeanette Kosorok, Michael R. Kosorok, Lindsey Littleton, M. Alison Marquis, Wanda K. O'Neal, David B. Peden, River Thomas Price, Pedro Miguel Quibrera, Cheyanne Ritz, Maria Sanchez, Stefanie Schwartz, Nicole Slye, Tianhao Song, Nicole Wilson, Tom Croxton, Jining Lu, Patricia Noel, Julie Bamdad, Steve N. Georas, Rosalind J. Wright
Institutions: University of Wisconsin–Madison, Brigham and Women's Hospital, Harvard University, Wake Forest University Health Sciences, Wake Forest University, University of Rochester Medicine, University of Rochester, Icahn School of Medicine at Mount Sinai, University of Kansas, University of Kansas Medical Center, University of North Carolina at Chapel Hill, Mayo Clinic in Arizona, University of California San Diego, Vanderbilt University, University of South Florida, University of Arizona, Yale University, Cleveland Clinic, Columbia University, University of California, San Francisco, University of Pittsburgh, Indiana University School of Medicine, University of California Davis Medical Center, University of California, Davis, University of Illinois Chicago, Northwestern University, University of Michigan, Boston Children's Hospital, Washington University in St. Louis, University of Colorado Anschutz, La Jolla Institute for Immunology, National Jewish Health, University of Colorado Denver, University of Chicago
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: San Diego Team Asthma Management using Phenotypes (STAMP), Center for Innovative TRIals in ChilDrEN and AdulTs (TRIDENT), PrecISE Network: ADAPT (Advancing Severe Asthma Precision Therapy), Clinical Centers for the NHLBI's Precision Interventions for Severe and/or Exacerbation Prone Asthma (PrecISE) Network (UG1), Reducing Airway Smooth Muscle Tone Using Inhaled Statins, The Great Lakes PrecISE Partnership, University of Kansas' Precision Biologic Interventions for Severe Exacerbation Prone Asthma (PrecISE) Clinical Center, PATINA - Precision Administration of Treatment in Neutrophilic severe Asthma, Chicago Metropolitan Asthma Consortium for severe / exacerbation-prone asthma, Type-2 or Not Type-2: That is the (Therapeutic) Question, Institutional Clinical and Translational Science Award, North Carolina Translational and Clinical Science Institute (NC TraCS), Sequential, Multiple Assignment, Randomized Trial in Severe Asthma Protocol (SMART-SA), Data, Modeling,and Coordination Center for PrecISE Network, Precision Interventions for Severe and/or Exacerbation Prone Asthma (PrecISE), UC San Diego Clinical and Translational Research Institute, Frontiers Clinical and Translational Science Institute at the University of Kansas, University of Pittsburgh Clinical and Translational Science Institute, University of Wisconsin Institute for Clinical and Translational Research, Research Training in Allergy and Clinical Immunology, Institutional Career Development Core, The Institute for Translational Medicine, Reducing Asthma Attacks in Disadvantaged School Children with Asthma, Clinical and Translational Science Institute
OpenAlex ID: W7129040615