Work

Discovery of Novel Heterotetracyclic DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Improved Oral Bioavailability and Potent Cancer Immunotherapy-Potentiating Activity

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c03630

Authors: Bingsheng Guan, Binbin Cheng, Shiyun Cheng, Jing-Jing Du, Congcong Wen

Institutions: University of Jinan, First Affiliated Hospital of Jinan University, Hubei Polytechnic University, Wenzhou Medical University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

Funder: National Natural Science Foundation of China

Award: G2073875684

OpenAlex ID: W7129040855

FWCI: 3.741

Cites: 28

Cited by: 2

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