Work

Metastatic castrate-resistant prostate cancer to the penis resulting in malignant priapism and urethral obstruction

Year: 2026

Type: article

Abstract: A 76-year-old male with metastatic castrate-resistant prostate cancer was found to have metastatic disease to the urethra and penis on PSMA PET scan. This resulted in constant pain due to obstruction of blood flow through the corpora cavernosum resulting in priapism and urethral obstruction. The patient underwent a radical penectomy, partial urethrectomy and perineal urethrostomy creation. Final pathology confirmed metastatic prostatic adenocarcinoma. Although rare, prostate cancer can metastasize to the corpora spongiosum or cavernosa. Treatment options are limited, and surgical excision with urinary diversion is likely to provide the most durable outcomes for one's quality of life.

Source: Urology Case Reports

DOI: 10.1016/j.eucr.2026.103380

Authors: Courtney Stewart, Joon Yau Leong, W. Kevin Kelly, Mihir S. Shah

Institutions: Thomas Jefferson University, Sidney Kimmel Cancer Center

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,160