Impact of pre-treatment food on praziquantel absorption, metabolism, treatment-associated side effects, and drug efficacy: a systematic review and meta-analysis protocol
Year: 2026
Type: review
Study design: Study Protocol
Abstract: BACKGROUND: Praziquantel is the drug of choice for parasitic diseases such as opisthorchiasis, schistosomiasis, and taeniasis. The U.S. Food and Drug Administration and World Health Organization (WHO) advise administering praziquantel with food to increase absorption and decrease side effects. However, there is a scarcity of evidence on the impact of food, and different types of food, on treatment outcomes. This review aims to address this knowledge gap by (i) examining how pre-treatment food intake is reported in humans, and characterising the types of food provided, if any, and (ii) assessing whether the presence and/or type of food impacts four key treatment outcomes in humans: absorption, metabolism, treatment-associated side effects, and drug efficacy. METHODS: We will search the following databases: Embase (via Ovid), MEDLINE (via PubMed), Web of Science Core Collection, Cochrane Central Register of Controlled Trials (CENTRAL), and African Index Medicus (via Global Index Medicus), and trial registries including clinicaltrials.gov and the WHO International Clinical Trials Registry Platform (ICTRP). Additionally, we will perform citation and grey literature searching and will contact researchers to obtain information on ongoing and unpublished relevant research. The search strategy is constructed using two core concepts: (i) praziquantel, and (ii) the outcomes of interest (pharmacokinetics, treatment-associated side effects, and drug efficacy). In Covidence, two review authors will independently screen the retrieved studies based on pre-defined inclusion/exclusion criteria and extract data using a standardised form. Risk of bias will be assessed using the Risk of Bias 2 (RoB 2) tool for randomised controlled trials and the Risk of Bias In Non-randomised Studies of Interventions (ROBINS-I) tool for non-randomised studies. Data will be synthesised narratively, and random-effects meta-analyses will be conducted to estimate the effect of food on the outcomes of interest, where appropriate. The certainty of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. DISCUSSION: This review has the potential to enhance treatment outcomes for individuals and communities living in endemic regions for schistosomiasis and other parasitic diseases treated with praziquantel. Our findings will be of direct relevance for WHO guidelines and, therefore, can help improve the design and impact of future targeted treatment and mass drug administration (MDA) programmes. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD420251024296.
Source: Systematic Reviews
Institution: University of Glasgow
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,090
Awards: Integrative Infection Biology - Mechanisms and Control of Disease, Interface tailoring and modelling for perovskite solar cells, G6064150800, G6093687916, A dual-country approach to double infections: assessing the impact of schistosomiasis and soil-transmitted helminthiasis on health and societal indicators in children and adults, Precision mapping of Schistosoma mansoni risk for targeted public health control and elimination
OpenAlex ID: W7129042376