Dimethyl sulfoxide acutely induces shear-dependent thrombosis in flow assays via red blood cell–dependent mechanisms
Year: 2026
Type: article
Abstract: Dimethyl sulfoxide (DMSO), widely used as vehicle solvent in hemostasis research, acutely induces massive platelet aggregation under arterial shear conditions in a dose-, time-, and shear-dependent manner. This red blood cell-dependent prothrombotic effect warrants immediate caution when interpreting microfluidic and flow-based thrombosis assays.
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,000
Awards: G1429133314, Clinical imaging inspired point-of-care microtechnology for enhanced diagnosis and monitoring of recurrent stroke, G232807111, G240310254, Novel 'Mechano-medicine' combats deadly sticky blood clots in diabetes, G38895355, CTCA-POC: CT Coronary Angiography Inspired Point-of-Care Technology for Enhanced Diagnosis and Monitoring of Coronary Artery Disease, G4904593443, G7529429903, Investigating gene expression profiles for thrombus formation on cerebrovasculature-on-a-chip platforms, G8429414716, Coronary artery mimicking blood clot test: A point-of-care prothrombotic prediction device for patient-specific diagnosis , G8605918427, Beyond White Clots: Decoding RBC Mechanosensing in Carotid Web Thrombosis for Innovative Stroke Prediction and Prevention, Developing Personalised and Portable Point-Of-Care Testing (POCT) Microtechnologies for Rapid Thrombotic Risk and Anticoagulant Dosage Assessment
OpenAlex ID: W7129047752