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Cobalt‐Catalyzed Coupling of 1,3‐Enynes and Acrylates to Access Trisubstituted and Tetrasubstituted Olefins

Year: 2026

Type: article

Abstract: A general cobalt‐catalyzed oxidative cyclization strategy for the stereoselective synthesis of tri‐ and tetrasubstituted alkenes from readily available 1,3‐enynes is presented. This method employs an earth‐abundant cobalt catalyst and exhibits broad functional group tolerance, delivering the multisubstituted olefins with high regioselectivity and excellent Z / E control.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202501202

Authors: Changliang Tan, Lina Ma, Jun Huang, Wenxin Lu, Qinglei Chong, Liang‐Hua Zou, Fanke Meng

Institutions: Jiangnan University, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, State Key Laboratory of Organometallic Chemistry, Nanjing University, Purdue University West Lafayette

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, Science and Technology Commission of Shanghai Municipality, National Key Research and Development Program of China, Beijing National Laboratory for Molecular Sciences

Awards: G1479749059, G3662619361, G3933364780, G6534365310, G6855975958

OpenAlex ID: W7129056737

FWCI:

Cites: 56

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