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Increased 99mTc-MAA Uptake in Supraclavicular Brown Adipose Tissue in a Pediatric Patient With Hereditary Hemorrhagic Telangiectasia

Year: 2026

Type: article

Abstract: A 10-year-old boy underwent a whole-body scan using 99mTc-labeled macroaggregated albumin (99mTc-MAA) to evaluate the underlying cause of hypoxemia. The scan demonstrated abnormally increased 99mTc-MAA uptake in the brain, thyroid, kidneys, and metaphyses of long bones-findings consistent with significant intrapulmonary shunting. Subsequent whole-exome sequencing confirmed a diagnosis of hereditary hemorrhagic telangiectasia. Notably, markedly increased 99mTc-MAA uptake was also observed in the supraclavicular brown adipose tissue.

Source: Clinical Nuclear Medicine

DOI: 10.1097/rlu.0000000000006376

Authors: Xia Lu, Bingyan Zhang, Cinian Lv, Wei Wang, Jigang Yang

Institutions: Capital Medical University, Beijing Friendship Hospital, Tsinghua University

Language: English

Topic: Vascular Anomalies and Treatments

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7129057605