Work

Electrochemical N‐hydroxyphthalimide Catalyzed Addition of α‐Alkoxy Radicals to Oxime Ethers

Year: 2026

Type: article

Abstract: In this work, we describe how N‐hydroxyphthalimide (NHPI), also under catalytic amounts, promotes hydrogen atom transfer (HAT) from alcohols under electrochemical conditions through the generation of phthalimide‐N‐oxyl (PINO). In contrast with the well‐known electrochemical oxidation to their corresponding aldehydes or ketones, α‐alkoxy radicals were successfully coupled with oximes promoting a carbon–carbon bond‐forming event. This method allows the α‐functionalization of primary and secondary alcohols under simple, straightforward, and mild electrochemical reaction conditions in a single operation even in the presence of catalytic amounts of the HAT catalyst.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70291

Authors: Rodrigo G. Enríquez, Juan S. Dato‐Santiago, Aitor Rivas‐Cobollo, José Alemán, Jose A. Fernández‐Salas

Institutions: Universidad Autónoma de Madrid, ORFEO-CINQA Research Network

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

Funders: Comunidad de Madrid, European Commission, HORIZON EUROPE Marie Sklodowska-Curie Actions