Year: 2026
Type: editorial
Abstract: High Resolution Image Download MS PowerPoint Slide The advent of immune checkpoint blockade therapy, exemplified by inhibitors targeting programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) axis, has revolutionized the landscape of clinical oncology. Despite its remarkable success, therapeutic benefits remain limited to a subset of patients, highlighting the urgent need for more accurate methods of patient stratification. Conventional techniques for assessing PD-L1 expression, such as immunohistochemistry, provide static and localized information but lack the ability to capture whole-body distribution or temporal dynamics. In contrast, positron emission tomography (PET) offers a noninvasive approach for visualizing PD-L1 expression and disease burden in vivo . However, clinical translation of PD-L1-specific radiotracers has been hampered by suboptimal tumor accumulation and unfavorable pharmacokinetics. To address this limitation, a recent study established a disulfide-directed multicyclic peptide (DDMP) platform capable of generating high-affinity peptide ligands specifically designed for PD-L1 imaging and potential therapeutic applications.
Source: ACS Medicinal Chemistry Letters
Authors: Lingxin Meng, Xiaoyan Li, Jimmy S. Patel, Steven H. Liang
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funder: National Institutes of Health
OpenAlex ID: W7129071307