Work

Copper catalyzed synthesis of thiazole derivatives from enaminones, amines and CS₂

Year: 2026

Type: article

Abstract: An efficient copper-catalyzed method for the synthesis of thiazoles from enaminones, amines, and carbon disulfide (CS₂) is described. This one-pot, ligand- and additive-free protocol proceeds under relatively simple reaction conditions, affording thiazole derivatives in good to excellent yields. Notably, CS₂ serves as a combined sulfur and carbon source, contributing to the synthetic practicality of the transformation. The method demonstrates good functional-group tolerance and provides a straightforward approach to biologically relevant thiazole scaffolds.

Source: Scientific Reports

DOI: 10.1038/s41598-026-40393-x

Authors: Amin Arman, Najmeh Nowrouzi, Mohammad Abbasi

Institution: Persian Gulf University

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,690

Funder: Persian Gulf University