Work

Electrochemical Migratory Cyclization of N ‐Acylsulfonimide and N ‐Arylsulfonyl Benzothiamide

Year: 2026

Type: article

Abstract: An electrochemical migratory cyclization of N ‐acylsulfonylimine readily generates the biologically interesting sulfonylimine‐functionalized benzothiazine. The implementation of continuous flow electrolysis further enhances reaction efficiency and enables gram‐scale synthesis of this heterocyclic framework, providing the material basis for future biological activity studies. In addition, a straightforward electrochemical entry to the previously inaccessible benzothiazepine from N ‐arylsulfonyl benzothioamide is developed.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70292

Authors: Lu‐Yao Wang, Ting Liu, Wei‐Zhen Wang, Xinglei He, Ke‐Yin Ye

Institution: Fuzhou University

Language: English

Topic: Phenothiazines and Benzothiazines Synthesis and Activities

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: Natural Science Foundation of Fujian Province

Award: G8607674867