Formulation and In-vitro Evaluation of Controlled Porosity Osmotic Pump Tablets of Telmisartan for Sustained Release Drug Delivery
Year: 2026
Type: article
Abstract: The purpose of the present research was for the development and assessment of controlled porosity osmotic pump (CPOP) tablets for the long-term oral administration of the poorly soluble hypertension medication telmisartan. The objective was to use an osmotic formulation technique that would improve the drug dissolution and bioavailability. FT-IR was used in order to confirm drug-excipient compatibility and validate analytical procedures. SLS was used as a pore-forming agent in a cellulose acetate membrane that was applied to tablets that were made by direct compression. A number of formulations were tested after it had been determined that all quality criteria satisfied requirements. Following zero-order kinetics, the lead formulation, F9C2 with a 5% coating, showed a steady, nearly full drug release (97.93% over 8 hours). Stability studies and SEM imaging confirmed the formulation's prolonged stability and consistent pore distribution, making it an appropriate approach for enhancing Telmisartan's therapeutic efficacy.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7129089960
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