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Photocatalytic Silacyclization of 1,7‐Enynes via Selective Functionalization of Si‐H/Silyl C(sp 3 )‐H Bonds: Access to Densely Functionalized Silacycles

Year: 2026

Type: article

Abstract: We report a highly efficient protocol for the synthesis of silacycles through oxidative annulation cascade with 1,7‐enynes via selective functionalization of Si‐H/silyl C(sp 3 )‐H bonds of hydrosilanes. Simple N ‐aminopyridinium salt acts as hydrogen atom transfer reagents for the in situ generation of sulfamidyl radical under photoredox catalytic condition. Notably, this protocol demonstrates broad substrate scope with shorter reaction time and viable to the late‐stage functionalization of natural products and pharmaceuticals.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70285

Authors: Ravikumar Ladumor, Sermadurai Selvakumar

Institution: Indian Institute of Technology Indore

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze