Late-systolic to early-diastolic hemodynamic force analysis in ischemic heart disease using vector flow mapping and invasive pressure measurement
Year: 2026
Type: article
Study design: Observational Study
Abstract: Hemodynamic force (HDF) analysis using vector flow mapping (VFM) enables noninvasive assessment of intraventricular pressure differences (IVPDs). In this study, we evaluated the apical suction from late systole to early diastole in patients with ischemic heart disease (IHD) with or without left ventricular aneurysm (LVA), validated against simultaneous left atrial–LV pressure measurements. A total of 37 participants were evaluated: 11 healthy controls, 11 patients with IHD without LVA, and 15 with LVA. VFM-derived IVPDs were quantified as IVPD recoil (late systole) or IVPD RF (early diastole). Patients with LVA showed markedly reduced IVPD recoil and the combined parameter (IVPD VFM recoil + RF) compared with those with IHD, indicating impaired apical suction. IVPD RF and the combined parameter (IVPD VFM recoil + RF) correlated with transmitral E-wave ( r = 0.54, P < 0.01 and r = 0.45, P = 0.03); the combined parameter (IVPD VFM recoil + RF) showed significant correlation with catheter-derived simultaneous pressure differences ( r = 0.40, P < 0.05). These findings demonstrate that VFM identifies loss of apical suction in LVA and reflects impaired LA–LV driving force. VFM offers a practical noninvasive tool for evaluating diastolic suction beyond Doppler indices and may improve physiological assessment in post-infarction LV remodeling.
Source: Heart and Vessels
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,790
Funder: Dokkyo Medical University
OpenAlex ID: W7129096345