Year: 2026
Type: article
Abstract: The optimized STN neuron model reproduces key features observed in experimental recordings, including spontaneous firing, action potential shape, hyperpolarization response, frequency-current relationship, and phase response to simulated synaptic input. In addition, the hybrid optimization strategy generated probability parameter distributions that not only improved the overall optimization results but also provided critical insights into how biophysical parameters influence firing characteristics.
Source: Journal of Neurophysiology
Authors: Hengji Chen, Cameron C. McIntyre
Institution: Duke University
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1427191688, G5520316217, G9000022566
OpenAlex ID: W7129096695