Work

The impact of body mass index on predicting postoperative pancreatic fistula in relation to pancreatic texture and main pancreatic duct diameter after pancreaticoduodenectomy

Year: 2026

Type: article

Abstract: Introduction: Pancreaticoduodenectomy (PD) remains the primary radical treatment for malignant periampullary tumors. Clinically relevant postoperative pancreatic fistula (POPF) develops in 15-20% of patients. Body mass index (BMI) may influence the risk of this complication. The aim of our study was to assess the impact of BMI, pancreatic texture, and main pancreatic duct diameter on the risk of POPF after PD. Methods: A retrospective cohort study included 106 patients who underwent PD for malignant periampullary tumors between 2018 and 2024, performed by a single surgical team at a major center in Ukraine. Patients were grouped according to a classification proposed by the International Study Group for Pancreatic Surgery (ISGPS) based on pancreatic texture and duct diameter: Group A: not-soft texture, duct > 3 mm. Group B: not-soft texture, duct ≤ 3 mm. Group C: soft texture, duct > 3 mm. Group D: soft texture, duct ≤ 3 mm. Results: Group A included 63 patients, Group B 9, Group C 8, and Group D 26. No significant association between BMI and POPF was found in Groups A, B, and C. However, in Group D, patients with BMI ≥ 25 had a significantly higher rate of POPF compared to those with BMI < 25. Conclusion: Increased BMI was significantly associated with a higher risk of POPF only in patients with a soft pancreatic texture and a main pancreatic duct diameter ≤ 3 mm.

Source: Surgery in Practice and Science

DOI: 10.1016/j.sipas.2026.100334

Authors: Oleksandr Kvasivka, Ruslan Pareniuk, Andrii Moiseienko, Illia Pepenin, Kostiantyn Kopchak

Institution: National Cancer Institute

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,020