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Hematopoietic stem cell transplant with a carrier donor rescues CD40L deficiency

Year: 2026

Type: article

Abstract: This study demonstrates successful hematopoietic stem cell transplant of CD40L deficiency using an asymptomatic carrier mother, leading to sustained 32% CD40L expression, normal recovery of T and B cell development and diversity, and expected growth and development 7.5 years post-transplant.

Source: Journal of Human Immunity

DOI: 10.70962/jhi.20250212

Authors: Christen L. Ebens, Smitha Hosahalli Vasanna, Diana Vilkama, Tamara C. Pozos, Attila Kumánovics, Alison Hornyak, Amir A. Sadighi Akha

Institutions: University of Minnesota, Children's Minnesota, Mayo Clinic

Language: English

Topic: Immunodeficiency and Autoimmune Disorders

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7129218828

FWCI:

Cites: 4

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