Work

Inferior metabolic control in isolated diabetic patients under the context of multimorbidity management: a comparative study

Year: 2026

Type: article

Abstract: PURPOSE: To explore the metabolic control status of patients with type 2 diabetes mellitus (T2DM) with or without hypertension or hyperlipidemia under the management of metabolic management centers (MMC). METHOD: Eligible patients with T2DM from the Yan’an University Affiliated Hospital Branch of the MMC were retrospectively enrolled and categorized into non-hypertensive and hypertensive groups, as well as non-hyperlipidemic and hyperlipidemic groups. Propensity score matching (PSM) was used to balance the baseline confounding variables. Intergroup comparisons of metabolic indicators were conducted and correlation analyses were performed for these indicators. RESULT: After PSM to balance baseline confounding factors, T2DM patients with hypertension or hyperlipidemia showed significantly better control of key metabolic indicators than those without these comorbidities. Specifically, the comorbid groups had lower levels of glycated hemoglobin (HbA1c), postprandial glucose, total cholesterol, and low-density lipoprotein cholesterol (LDL-c). Additionally, the insulin resistance index (HOMA-IR) correlated with triglyceride and high-density lipoprotein cholesterol (HDL-c) levels, further reflecting the metabolic advantages associated with comorbidities under standardized management. CONCLUSION: T2DM patients without hypertension or hyperlipidemia have poorer metabolic control under MMC management, emphasizing the need for tailored management strategies for this “potentially underprioritized group.” CLINICAL TRIAL NUMBER: Not applicable.

Source: BMC Endocrine Disorders

DOI: 10.1186/s12902-026-02195-0