Soluble cytokine receptor levels in obstructive sleep apnea patients treated with continuous positive airway pressure therapy
Year: 2026
Type: article
Abstract: Aims: Continuous positive airway pressure (CPAP) is an established therapy for obstructive sleep apnea (OSA), but how CPAP compliance changes inflammation/cytokine activation remains unclear. Materials and methods: Plasma from patients with OSA (n = 50) and control subjects (n = 6) were subjected to soluble cytokine receptor profiles – an index of cytokine activation. Results: With OSA, plasma levels of sCD30, sEGFR, sIL1RII, and sVEGFR2 increased by over 2-fold (p < 0.05). In CPAP-compliant patients (n = 22), Plasma levels of sCD30, sEGFR, sIL1RI, sIL1RII, sIL2Ra, sVEGFR1, and sVEGFR2 decreased in CPAP compliant patients (n = 22) after 90 d of CPAP, whereas in CPAP non-compliant patients (n = 28), these soluble cytokine profiles remained unchanged. Conclusions: These results identified that a specific set of soluble cytokine receptors, including sCD30, sEGFR, sIL1RII, and sVEGFR2, may serve as indices of cytokine activation in patients with OSA and also identify therapeutic response such as CPAP.
Source: Future Science OA
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,165
Awards: G1334203038, Therapeutic targeting of tissue inhibitor-4 in hypertrophy and failure, Imaging the Atherosclerosis Cascade in Sleep Apnea, Multidisciplinary Research Training in Sleep Science, Use of Novel Multi-modality Imaging to Evaluate the Relationship Between Sleep Duration, Vascular Inflammation, and Visceral Adiposity, G993129303
OpenAlex ID: W7129255378