Ultrasound biomicroscopy-based quantitative assessment of anterior segment biometric changes in contralateral eyes of unilateral neovascular glaucoma: a retrospective case-control study
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: Neovascular glaucoma (NVG) is a blinding ocular disease secondary to severe retinal ischemic disorders, characterized by rapid progression and severe visual impairment. While most studies focus on diagnosis and intervention of affected eyes in NVG, systematic evaluation of structural status and potential risks in fellow eyes remains insufficient. Objective: This study aims to quantitatively analyze anterior segment structures in fellow eyes of unilateral NVG patients using ultrasound biomicroscopy (UBM), identify differences from normal eyes, and investigate age-related variations in anterior segment parameters along with their diagnostic efficacy. Methods: This retrospective case-control study included fellow eyes of unilateral NVG patients (observation group) and age- and gender-matched normal eyes (control group). UBM-measured parameters included anterior chamber depth (ACD), angle opening distance (AOD500/750), trabecular-iris angle (TIA500/750), iris thickness (IT500/750/2000), iris convexity (IC), trabecular-ciliary process distance (TCPD), and iris-cornea posterior surface distance (ICPD). Age-stratified analysis, parameter correlation, and ROC curve evaluation were performed. Results: < 0.05). These differences were more pronounced in elderly subgroups, with IC, ACD, and AOD750 demonstrating strong discriminative power in ROC analysis (AUC > 0.7). Correlation analysis revealed AOD500 was positively associated with ACD and TIA but negatively with IC and IT750, suggesting interconnected angle anatomy modulated by age. Conclusion: Fellow eyes of unilateral NVG patients exhibit multiple abnormal anterior segment alterations despite being clinically unaffected, particularly in the elderly. UBM provides reliable quantitative indicators for early high-risk identification, with IC, ACD, and AOD750 serving as potential warning parameters, laying a theoretical foundation for risk screening models and preventive strategies.
Source: Frontiers in Medicine
Authors: Fang Lin, Yuwei You, Yuxing Su
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7129272211