Work

Direct Access to Dihydrophthalazine‐1‐Carboxamides via a Ugi‐Type Dearomatization Multicomponent Process

Year: 2026

Type: article

Abstract: ABSTRACT A metal‐free, Ugi‐type dearomatization strategy for the efficient synthesis of dihydrophthalazine derivatives is described. This transformation enables the direct and efficient assembly of dihydrophthalazine‐1‐carboxamide scaffolds under mild conditions. The optimized process accommodates a broad range of substrates, including acyl chlorides, chloroformates, and both aromatic and aliphatic isocyanides, affording the desired products in good yields. This method offers notable advantages such as atom economy, operational simplicity, and wide functional group tolerance, providing efficient access to biologically relevant dihydrophthalazine frameworks.

Source: Journal of Heterocyclic Chemistry

DOI: 10.1002/jhet.70173

Authors: Wenke Xu, Sufan Zhou, Huimin Zhang, Yipo Xi, Zhuoya Mao

Institutions: Shanxi Medical University, Henan Police College, Zhengzhou University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Natural Science Foundation of Shanxi Province, Natural Science Foundation of Henan Province, Henan Provincial Science and Technology Research Project

Awards: G1666266112, G4988047252, G5992987588