Nutritional and inflammatory biomarkers predicting hospitalization length in acute decompensated heart failure EF below 50%
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: Despite evidence on nutritional and inflammatory markers in various conditions, their combined impact on outcomes in acute decompensated heart failure (ADHF) with reduced left ventricular ejection fraction (LVEF <50%) remains underexplored. This study investigated associations between these biomarkers and clinical outcomes in ADHF patients with LVEF <50%. Methods: This retrospective study included 232 patients with ADHF hospitalized between January and December 2024. Patients were grouped by hospitalization length (0-5 vs. > 5 days). Nutritional and inflammatory biomarkers were calculated from admission blood samples and analyzed with demographic and clinical characteristics using appropriate statistical methods. Results: < 0.001) as independent predictors of shorter hospitalization. ROC analyses demonstrated PNI (cut-off = 40.51, AUC = 0.85, sensitivity 77%, specificity 77%) outperformed HALP (cut-off = 0.3585, AUC = 0.679, sensitivity 63%, specificity 63%) in predicting shorter stays. SII (cut-off = 983.60, AUC = 0.622) and SIRI (cut-off = 2.917, AUC = 0.626) were associated with prolonged hospitalization but showed limited predictive accuracy. Conclusion: In ADHF patients with LVEF <50%, poor nutritional status (low HALP and PNI) and high inflammatory burden (elevated SII and SIRI) were linked to prolonged hospitalization. Higher HALP and PNI predicted shorter stays, with PNI showing superior discriminatory power, suggesting nutritional optimization may improve outcomes.
Authors: Mehmet Özyaşar, Tolga Memioğlu
Institutions: Konya City Hospital, Bolu Abant İzzet Baysal University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7129332012