Work

Antibiotic Therapy and Factors Predicting Prolonged Hospitalization Among Children Under Three Years Diagnosed With Respiratory Syncytial Virus‐Associated Lower Respiratory Infection

Year: 2026

Type: article

Abstract: ABSTRACT Background Respiratory syncytial virus (RSV) is a common cause of lower respiratory infections (LRIs) in infants and young children. Antibiotic overuse remains a significant concern in hospitalized children with RSV‐associated LRIs. This study aimed to investigate the prevalence of antibiotic use and identify predictors of prolonged hospitalization in children with RSV‐LRIs. Methods A retrospective record review study was conducted at Abha Maternity and Children's Hospital, enrolling 162 children aged 1–36 months admitted with RSV‐associated LRIs between January and December 2022. Demographic, clinical, laboratory, and imaging data were collected. Antibiotic therapy and hospital length of stay (LOS) were also retrieved and analyzed. Results Of the 162 patients, 147 (90.74%) received antibiotic therapy, with azithromycin, cefuroxime, and ceftriaxone being the most commonly used. Patients who received antibiotics had a significantly longer median LOS compared to those who did not (6 vs. 3 days, p < 0.001). Factors associated with prolonged LOS (≥ 5 days) included antibiotic therapy use (odds ratio [OR] = 7.47 (95% confidence intervals [CI]: 2.18−25.57), pneumonia: OR = 3.58 (95% CI: 1.67−7.67), age < 12 months: OR = 2.80 (95% CI: 1.32−5.89), consolidation: OR = 2.54 (95% CI: 1.16−5.59), age in months: OR = 0.94 (95% CI: 0.91−0.98) (indicates decreasing odds with increasing age), admission respiratory rate: OR = 1.04 (95% CI: 1.01−1.07), and admission peripheral oxygen saturation (SpO 2 ): OR = 0.91 (95% CI: 0.86−0.97) (indicates decreasing odds with higher SpO 2 ). Conclusion The high prevalence of antibiotic use in this study highlights the challenges in differentiating RSV‐LRIs from bacterial pneumonia. Independent predictors of prolonged hospital stay included antibiotic therapy, pneumonia, younger age, lower admission SpO₂, and higher respiratory rate.

Source: Immunity Inflammation and Disease

DOI: 10.1002/iid3.70370

Author: Ali Alsuheel Asseri

Institution: King Khalid University

Language: English

Topic: Respiratory viral infections research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,300