Role of C-reactive protein and fibreoptic endoscopic evaluation of swallowing as early markers of stroke-associated pneumonia
Year: 2026
Type: article
Study design: Observational Study
Abstract: Introduction Stroke may result in dysphagia, which can subsequently lead to stroke-associated pneumonia (SaP). This condition has been shown to exert a significant negative impact on patient outcome. Early diagnosis and prevention are therefore desirable. Methods This retrospective study compared inflammatory markers during the first 4 days after stroke in 515 patients from 2015 and 2021, analyzing associations with dysphagia, year of treatment, dietary adjustments, stroke-associated pneumonia, and antibiotic use. Data entry and descriptive analyses were performed using Microsoft Excel ® . Datasets from 2015 and 2021 were analyzed in SPSS ® (IBM SPSS Statistics 27). Results This retrospective analysis demonstrates that dysphagia significantly influences C-reactive protein (CRP) levels within the first 4 days after stroke. Dysphagia and elevated CRP are early markers of emergence of stroke-associated pneumonia, whereas leukocyte count and temperature show limited forewarning value. The combination of post-stroke inflammatory response, dysphagia (PAS > 5), and elevated CRP may serve as an early indicator of SaP and support timely FEES-based assessment. Discussion Early elevated CRP levels in dysphagic stroke patients are indicative of aspiration-related inflammation and may serve as a sensitive early biomarker for stroke-associated pneumonia. The combined assessment of dysphagia severity and CRP supports improved early risk stratification and preventive management.
Source: Frontiers in Stroke
Institution: Kantonsspital Münsterlingen
Language: English
Subfield: Speech and Hearing
Field: Health Professions
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,353
OpenAlex ID: W7129445288