Work

Asymmetric Negishi and Kumada Couplings

Year: 2026

Type: article

Abstract: This review provides a comprehensive overview of asymmetric Negishi and Kumada crosscoupling reactions, covering key developments from the 1980s through 2025. It examines enantioselective and enantiospecific variants catalyzed by nickel, palladium, and cobalt complexes. The review discusses reaction scope, mechanistic ligand design and mechanistic understanding have enabled increasingly challenging transformations with high enantioselectivity Overall, this review demonstrates the power and versatility of asymmetric Negishi and Kumada couplings as valuable tools for constructing chiral molecules.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70204

Authors: Rui‐Heng Wang, Aishun Ding, Ramon Rios

Institutions: Fudan University, Khalifa University of Science and Technology

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

OpenAlex ID: W7129464421

FWCI: 1.871

Cites: 64

Cited by: 1

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