Migrasome as a novel organelle: Biogenesis, physiological functions, and therapeutic potential
Year: 2026
Type: article
Abstract: Migrasomes are a recently identified type of membranous organelle formed during cell migration. They are produced by migratory cells and widely distributed across various cells and tissues. Migrasomes contain abundant signaling and bioactive molecules, playing crucial roles in embryonic development, angiogenesis, material transport, mitochondrial quality control, and coagulation, as well as participating significantly in numerous pathological processes. This paper provides a detailed overview of the latest advancements in migrasome biology research, including migrasome biogenesis, physiological functions, isolation, and identification, and their roles in the onset, progression, diagnosis, and treatment of clinical diseases. In addition, we propose novel hypotheses and outline future research directions addressing current challenges and potential clinical applications of migrasomes, which may inform their utilization in future clinical diagnostics and therapeutics.
Authors: Rumeng Tang, Ling Zhou, Jiaran Lin, Xiangyuan Zhang, Pengfei Xie, Lili Zhang, Linhua Zhao, Xiaolin Tong
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $1,130
OpenAlex ID: W7129481171