Eco-friendly nanocarriers for mosquito larvicide: calcium carbonate submicron particles encapsulating plant extracts
Year: 2026
Type: article
Abstract: Dengue is an arboviral disease transmitted by Aedes aegypti and Aedes albopictus mosquitoes. Natural plant-based insecticides are promising alternatives to chemical insecticides but face challenges, including rapid degradation of bioactive compounds in aquatic environments. In this study, bioactive plant extracts were encapsulated in water-insoluble CaCO 3 submicron carriers, which are of great interest as targeted drug delivery systems due to their bioadhesive, biocompatible properties, and eco-friendly nature. This approach was applied to achieve the highest efficiency with controlled release of bioactive compounds targeting dengue mosquito larvae. CaCO 3 submicron particles were synthesized using a mixture of Ca(CH 3 COO) 2 and NaHCO 3 in H 2 O and diethylene glycol as solvents. The combined plant extract of Capsicum frutescens (Naimiris) and Allium sativum (garlic), which showed significant larvicidal activity against dengue mosquito larvae, was encapsulated into CaCO 3 particles, and their release properties and larvicidal activity were examined. The results of the SEM, XRD, XRF, and FTIR analyses confirmed the morphology, structure, and chemical characterization of the CaCO 3 submicron particles. Qualitative phytochemical analysis was also conducted, and the total phenolic and total flavonoid contents were investigated quantitatively. The diameter of CaCO 3 particles was 252.3–676.4 nm, and the average size was 419.7 nm. 85.56 ± 4.65% of plant extract was encapsulated into CaCO 3 particles, and about 27% of the encapsulated product was released to the medium up to 10 days. Larvicidal activity showed concentration and time-dependent mortality in mosquito larvae, resulting in up to 55% mortality after 10 days for the highest concentration tested. The results confirmed that CaCO 3 submicron carriers are effective as slow-release drug delivery systems.
Source: Tropical Medicine and Health
Institutions: University of Peradeniya, Macquarie University
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,990
OpenAlex ID: W7129515793