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Extracellular Vesicle Analysis: Recent Technological Advances and Emerging Opportunities

Year: 2026

Type: review

Abstract: Extracellular vesicles (EVs) are membrane-bound vesicles that mediate intercellular communication and have gained significant interest as potential biomarker sources and therapeutic agents. This review summarizes the most recent advances in EV analysis, including an overview of EV biology, current approaches for EV isolation and enrichment, and emerging technologies for EV detection, with a particular focus on single-EV analysis. We also examine the integration of artificial intelligence into EV research. This review provides a broad perspective into the landscape of EV analysis and highlights potential future directions in this rapidly evolving field to improve the analytical rigor and translational potential of EV-based diagnostics and therapeutics.

Source: Annual Review of Analytical Chemistry

DOI: 10.1146/annurev-anchem-070325-084902

Authors: Yunjie Wen, Jingzhu Shi, Yuxin Deng, Quinn Shepard, Xinyuan Gao, Yong Zeng

Institutions: University of Florida, University of Florida Health, UF Health Cancer Center

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

OpenAlex ID: W7129524015

FWCI: 0.905

Cites: 124

Cited by: 1

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