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Spontaneous Ecchymosis as Initial Presentation of Acquired Hemophilia A

Year: 2026

Type: article

Abstract: Hemophilia A, a deficiency of clotting factor VIII, can be congenital, presenting with joint bleeding in childhood, or acquired, a rare subtype presenting as spontaneous bleeding most commonly seen in older adult patients. This report outlines an older adult patient with no history of bleeding disorders who developed acute-onset spontaneous ecchymoses and was found to have acquired hemophilia A. This case demonstrates the importance of a broad differential diagnosis in ecchymoses in older adult patients that includes coagulation factor deficiencies despite a lack of hematologic history. Early diagnosis and treatment of hemophilia A with hemostatic control and inhibitor eradication are imperative to prevent life-threatening bleeding.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2025.1190

Authors: Lahari Ramagiri, Anna L. Farrell, Julie Kielt

Institutions: The Ohio State University, The Ohio State University Wexner Medical Center

Language: English

Topic: Hemophilia Treatment and Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7129524449

FWCI:

Cites: 8

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