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Unveiling the Link: Exploring the Association Between Cancer and Leukocyte Chemotactic Factor 2 (ALECT2) Amyloidosis

Year: 2026

Type: article

Abstract: We present a case of a 53-year-old Hispanic man with mantle cell lymphoma who developed progressive decline in estimated glomerular filtration rate despite no previous kidney disease or predisposing conditions. Findings of a renal biopsy revealed leukocyte chemotactic factor 2 (ALECT2) amyloidosis. Remarkably, after treatment of his lymphoma, the patient's estimated glomerular filtration rate normalized. Given the correlation between the patient's cancer and the improvement in kidney function after treatment, we hypothesize that his lymphoma may have acted as a trigger for ALECT2 amyloidosis through 1 or more potential mechanisms, including dysregulated Wnt/β-catenin signaling, tumor-related inflammatory pathways, or a second hit on an underlying genetic predisposition.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2025.0374

Authors: Veena Ganesan, Rahul Maheshwari, Priya Desphande, Matthew Abramson

Institutions: Icahn School of Medicine at Mount Sinai, Albert Einstein College of Medicine, Mount Sinai Hospital

Language: English

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7129567086

FWCI:

Cites: 16

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