Year: 2026
Type: article
Abstract: Innate immune cells can retain molecular imprints of past encounters long after the initial stimulus has ceased. In this issue, Gorin et al. (https://doi.org/10.1084/jem.20250976) reveal an unexpected mechanism by which IFN-γ sustains trained immune states through prolonged signaling driven by cytokine retention at the cell surface.
DOI: 10.1084/jem.20252624
Authors: Luca Frosio, Renato Ostuni
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funders: Fondazione AIRC per la ricerca sul cancro ETS, American Association for Cancer Research, Lustgarten Foundation, Swim Across America, Fondazione Telethon, Ministero della Salute, Associazione Italiana per la Ricerca sul Cancro, Fondazione Regionale per la Ricerca Biomedica, European Research Council
OpenAlex ID: W7130316075