Work

An immune-mediated effect of the antibiotic cefiderocol on LPS-induced acute lung injury

Year: 2026

Type: article

Abstract: This study examines the immune-modulatory effects of cefiderocol in a murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Cefiderocol pretreatment significantly reduced lung tissue damage, lowered pro-inflammatory cytokines, and decreased ferroptosis markers. Its protective effect was comparable to that of the ferroptosis inhibitor ferrostatin-1, while cefepime showed limited efficacy. These findings suggest that cefiderocol has an immuno-mediated role in LPS-induced ALI, potentially by modulating ferroptosis and inflammation, warranting further investigation for sepsis-related complications. IMPORTANCE: This study examines the immune-modulatory effects of cefiderocol in a murine model of LPS-induced acute lung injury (ALI). Cefiderocol pretreatment significantly reduced lung tissue damage, lowered pro-inflammatory cytokines, and decreased ferroptosis markers. Its protective effect was comparable to that of the ferroptosis inhibitor ferrostatin-1, while cefepime showed limited efficacy. These findings suggest that cefiderocol has an immuno-mediated role in LPS-induced ALI, potentially by modulating ferroptosis and inflammation, warranting further investigation for sepsis-related complications.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01634-25

Authors: Min Hao, Ying Li, Yingmin Bi, Shuang Liu, Mohan Ju

Institutions: Fudan University, Huashan Hospital

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Shanghai Municipal Health Commission, National Natural Science Foundation of China