MEK inhibition alleviates macrophage overactivation without compromising the efficacy of CAR ‐T‐cell therapy
Year: 2026
Type: article
Abstract: This study presents mitogen-activated protein kinase kinase (MEK) inhibition as a strategy for cytokine release syndrome (CRS) and secondary haemophagocytic lymphohistiocytosis (sHLH) in chimeric antigen receptor (CAR)-T therapy, utilizing MEK's regulatory actions that target macrophage activation, cytokine secretion from both macrophages and CAR-T cells, supported by evidence of unimpaired CAR-T-cell therapeutic efficacy of alleviated CAR-T-related inflammation.
Source: British Journal of Haematology
DOI: 10.1111/bjh.70364
Authors: Hui Li, Youming Wang, Yingxiang Wang, Li Ding, Sujun Li, Miaomiao Wu, Qianwen Xu, Yuanli Chen, Xingbing Wang
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G2199692753, G2388695857
OpenAlex ID: W7130320916