Work

A combinatorial CAAR-T cell strategy to eliminate factor VIII inhibitors in preclinical models of hemophilia A

Year: 2026

Type: article

Abstract: target cell expansion. These findings demonstrate that CAAR-T therapy, particularly the combinatorial approach, holds promise for addressing FVIII inhibitor formation in hemophilia A, offering a targeted and effective treatment strategy.

Source: iScience

DOI: 10.1016/j.isci.2026.114924

Authors: Wenjie Li, Qirui Yang, Shuping Lai, Rongfang Wei, Lisheng Cai, Xue Zhang, Xin He, Yan Chen

Institutions: Eighth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Shenzhen Second People's Hospital, Guangdong Pharmaceutical University

Language: English

Topic: Hemophilia Treatment and Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Natural Science Foundation of China, Science, Technology and Innovation Commission of Shenzhen Municipality

Awards: G3075209521, G5999724082

OpenAlex ID: W7130325255

FWCI:

Cites: 30

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